Aging is an inevitable stage of life where the human body is put to the ultimate test. In the earlier stages of one’s life, the body’s ability to deliver on different aspects of wellness is likely to have many people in awe, paying respect to themselves. Naturally, with time, the body stops fighting to win and accepts that it also has its limits. And exactly where do these limitations exist? A very common issue that people approaching their mid-thirties and above face is in the form of nerve pain.
Though nerve damage might result from hard-to-reverse health conditions, there are a number of others that are controllable. After spending some time on this matter, our editorial team came across one company whose dietary supplement targets the root cause of neuropathic and related pain sources. Without further delay, here’s a comprehensive review of ProNervium.
What is ProNervium?
ProNervium is a nerve health-focused dietary supplement that addresses the underlying cause of nerve issues. The creators at the Institute of Neuropathy believe that their formulation can help men and women from 35 to 80 years of age, no matter how severe their nerve discomfort might be. Each serving has been equipped with nothing more than medicinal mushrooms, each of which is reckoned to target and reverse the culprit under question.
This potentially means inhibiting pain receptors, increasing nerve and neurite growth targets, and maintaining a strong connection between the brain and the rest of the body. With that, let’s discuss the Institute of Neuropathy team’s strategy for ProNervium.
How does ProNervium work?
ProNervium focuses on rectifying the effects of neurite degeneration on nerve health. Neurites are neuronal processes that refer to any projection (normally an axon or a dendrite) from the cell body of a neuron, writes one source. In other words, it is a term thrown around to describe the development of neurons and, eventually, nerve health. So, what do we know about neurite degeneration? As reported in a publication, degeneration implies progressive dysfunction in the axons or dendrites and morphological changes, resulting in a loss in neurite integrity.
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There are several causes of neurite degeneration. First, it has been characterized by an excess accumulation of proteins containing alpha-synuclein (possibly leading to mitochondrial problems) in toxic clumps. Second, it might result from declining levels of dopaminergic neurons responsible for cognition, movement, and executive functions. Lastly, it could be due to cognitive and motor symptoms. The technicalities aside, it is important to understand that neurite degeneration has been associated with several neurodegenerative disorders.
Considering the consequences of neglecting neurite degeneration, the team at the Institute of Neuropathy claims to have relied on clinical evidence to formulate ProNervium. To understand why mushrooms were selected, it is imperative to see which one made the cut and how they might contribute to the formula.
What ingredients are in ProNervium?
The main ingredients in ProNervium are:
Cordyceps Sinensis Powder – Mycelium (266 mg)
Cordyceps sinensis is a parasitic fungus normally hand-picked, dried, and used predominantly in traditional Chinese Medicine. Based on available studies, there is evidence to suggest that this type of mushroom can fight inflammation. In particular, it might suppress specific types of proteins linked to inflammation. These include natural killer (NK) cell activity, tumor necrosis factor-alpha (TNF-alpha), phytohemagglutinin (PHA), and interleukin-2 (IL-2).
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One study that looked at Cordyceps's effect on neurite outgrowth (or the development of neurons) found that it reversed scopolamine-induced declines in memory and increased choline acetyltransferase (which is responsible for the development of the acetylcholine neurotransmitter) expressions. This led the researchers to conclude that Cordyceps might protect individuals from neuronal degeneration in the brain.
Reishi Mushroom Extract – Fruiting Body (266 mg)
The reishi mushroom (Ganoderma lucidum or lingzhi) is the second fungus qualified for ProNervium. Still, according to an article, it mostly thrives in hot and humid locations in Asia. A 2013 study focused on the possible pharmacological traits of reishi mushrooms that trigger neurite outgrowth, and this type significantly promoted neurite regrowth, specifically in neuroblastoma (N2a) cells. This led researchers to argue for reishi for cognitive and brain functions.
Moreover, they emphasized that reishi mushrooms contain nerve growth factor (NGF)- like compounds. The latter is critical for neuronal health, considering that NGF is involved in target neuron development, growth, maintenance, and proliferation.
Shiitake Mushroom Extract – Fruiting Body (266 mg)
Shiitake mushroom extract is made from one of the most popular fungi known to humankind. Native to East Asia, it is best known for its rich, savory taste profile and its nutritional profile. Speaking of benefits, this mushroom might support heart health thanks to key compounds such as eritadenine (known for blocking the production of cholesterol), sterols (known for blocking the gut’s ability to absorb cholesterol), and beta-glucans (known for lowering cholesterol levels). Other ways in which shiitake might improve nerve health are by improving immune markers, lowering inflammation levels, and reducing oxidative stress.
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Lion’s Mane – Fruiting Body (266 mg)
The lion’s mane mushroom is a large, white, shaggy mushroom that resembles a lion’s mane over time. This type carries a wide range of bioactive substances that positively affect the brain, heart, and gut. The brain might help grow and form new connections, which normally decrease with age. Lion’s mane mushroom’s hericenone and erinacine concentrations are poised to stimulate the growth of brain cells and nerve growth while protecting people from the risk of developing Alzheimer’s disease.
This mushroom might also prevent damage brought on by the accumulation of amyloid-beta plaques. Moreover, its anti-inflammatory properties might help improve hippocampus functioning by lowering anxiety and depressive symptoms. Finally, some studies suggest that lion’s mane might help speed the recovery of nervous system injuries by ensuring healthy growth and reparation of nerve cells.
In addition to the above-listed ingredients, there’s also the proprietary blend (266 mg) of fruiting bodies such as:
Maitake Mushroom: Reduce inflammation and increase neurogenesis (or promote the development of new neuron cells)
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Turkey Tail Mushroom: Improve cognitive function and reduce inflammation and age-related decline
Chaga Mushroom Extract: Fight inflammation and lower blood sugar and cholesterol levels
Sun Mushroom: Might protect immune and liver functions, regulate diabetic symptoms, and exert anticancer and antiviral activities
White Button Mushroom: Might have cancer-fighting properties, promote heart health, improve gut health, and regulate blood sugar levels
Wood Ear Mushroom: Might help fight cancer, support heart health, and fight inflammation
Frequently Asked Questions (FAQ)
Q. What is the difference between mycelium and fruiting bodies?
A. One source writes that mycelium is the part of the mushroom that grows below the surface, whereas the fruiting body consists of the stalk, cap, gill, skirts, and other parts attached to the stalk and cap. Compared to mycelium, the nutritional profile of fruiting bodies is far superior, especially in beta-glucan contents, which is one of many factors that give medicinal mushrooms their healing powers.
Q. Who is ProNervium suitable for?
A. ProNervium is suitable for anyone who is suffering from bodily discomfort brought on by declines in nerve health.
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Q. Is ProNervium safe?
A. According to the creators, ProNervium is an all-natural supplement manufactured in the USA at an FDA-registered, GMP-certified facility under strict and sterile standards. Moreover, each ingredient is soy-free, dairy-free, vegetarian-friendly, and non-GMO, making it useful for a larger group.
Q. How should I take ProNervium?
A. To make the most of ProNervium, individuals should take two capsules daily with adequate water.
Q. How long will it take to see results with ProNervium?
A. The Institute of Neuropathy team believes ProNervium benefits will likely be seen immediately after taking the first of several servings. However, strengthening the nerves and ensuring healthy neurite outgrowth takes time. Therefore, individuals are recommended to take each serving regularly and to monitor their progress at the one-week, one-month, three-month, and six-month marks.
Q. What is the estimated arrival time for ProNervium shipments?
A. ProNervium shipments to the continental United States should arrive in 4 to 7 business days. Otherwise, depending on the country and its customs procedures, it could take up to 14 business days.
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Q. Does A money-back guarantee protect proNervium?
A. Yes, ProNervium has been protected by a 180-day money-back guarantee. If individuals feel that the first 180 days of taking this supplement were completely meaningless for their overall nerve health, customer service can be reached regarding refunds. This might only apply to unused bottles, but to confirm, here are some points of contact worth jotting down:
- Email: support@instituteofneuropathy.com
- Returns address: 19655 E 35th Dr., #100 Aurora, CO 80011, USA
- Mailing address: 71-75 Shelton Street, Covent Garden, London, WC2H 9JQ, UK
How much does ProNervium cost?
Each ProNervium bottle contains enough capsules to last one month. Once again, improving and strengthening nerve health takes time, which is why the creators decided on the below-listed pricing to encourage bulk purchases:
- 1 ProNervium bottle: $69 each + applicable shipping
- 3 ProNervium bottles: $59 each + free U.S. domestic shipping
- 6 ProNervium bottles: $49 each + free U.S. domestic shipping
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Final Verdict
To summarize, ProNervium is an all-natural supplement that aims to target neurite degeneration and its associated consequences. With time, this supplement is expected to help strengthen and rejuvenate nerves, eliminating any discomfort caused by nerve damage. Most of all, complex connections between the brain and the body are said to improve, liberating people from pain and other health conditions revolving around nerve function. Our research of the ingredients does suggest that medicinal mushrooms have quite a role to play in this health issue.
In particular, a few studies appear to support the claims that the ingredients in ProNervium can promote the development of new neurons, fight inflammation, and increase neurite outgrowth. As promising as these results are, they are mainly based on animal studies, making it difficult to say whether humans can experience similar effects. Naturally, more research is still needed despite the promising angle.
A shining light worth mentioning is that the dosage of each ingredient is available, demonstrating that the creators value transparency and have done their research to assess the strength of their solution.
It also makes it easier for individuals to decide whether ProNervium suits them. All this to say, ProNervium may improve nerve-related pain, but it might not necessarily be the all-in-one solution. Put differently, individuals might see value in ProNervium as an adjunct to an existing treatment plan or anti-inflammatory diet.
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